JBC: Cell's "network social"

Recently, researchers from the Second Military Medical University, Jilin University and other institutions have revealed a new signaling mechanism of integrin-linked kinase-related phosphatase (ILKAP) regulating cell survival and apoptosis in new research. Related papers were published in the Journal of Biochemistry (JBC). Professor Xiao Jianru and Professor Liu Tielong of the Second Military Medical University are co-corresponding authors of this article. Recently, researchers from the Second Military Medical University, Jilin University and other institutions have revealed a new signaling mechanism of integrin-linked kinase-related phosphatase (ILKAP) regulating cell survival and apoptosis in new research. Related papers were published in the Journal of Biochemistry (JBC). Professor Xiao Jianru and Professor Liu Tielong of the Second Military Medical University are co-corresponding authors of this article. The former is mainly engaged in basic clinical research on spinal tumors and spinal injuries. The latter has long been engaged in clinical work of spinal surgery and related research.

Integrin-linked kinase-associated phosphatase (ILKAP) is a new member of the protein phosphatase 2C (PP2C) family. Although the international knowledge of it is still very limited, preliminary research results have shown that this is a kind of Signal pathways are closely related to protein phosphatases. ILKAP is widely expressed in human tissues, with high levels of expression in skeletal muscle, kidney, and liver. Mediating apoptosis is the main physiological function of ILKAP, and therefore has a close relationship with the occurrence and development of tumors and other diseases.

ILKAP, which can regulate cell survival and apoptosis, is only one member of the human cell communication network. Cell communication is a theory aiming at the principles of cell physiology. According to this theory, there is no static relationship between cells and between cells and environment, and information transmission and interaction are constantly carried out between each other. The information sent by any one cell can be transmitted to another cell through the medium, and respond accordingly. This communication activity plays an important role in human life activities. Through the communication and interaction of signals between cells, these immobile cells that are separated by "miles" are connected into an organic whole, forming a huge and complex information network. Through this network, the substances and energy in the metabolic activities are accurately regulated to the places needed to maintain the normal physiological activities of the body. At the same time, any diseased or damaged cells will be identified, and the network will send cell signals to control the cells to repair or "suicide". Cancer cells that are mutated and proliferate abnormally will also be recognized by this network under normal circumstances and removed by cell communication mechanisms.

Just as the network will be disconnected and transmission errors occur in reality, various problems will occur in the transmission of information between cells. With the increase of human age, the frequency and probability of any obstacle or interruption in cell communication also increase. When the cell communication is wrong in terms of time, space, and quantity, it will cause the wrong reaction of the cell, and the body will be hit, resulting in disease. Conversely, when the correct information is passed to the cells, those damaged or senescent cells will be activated to repair themselves and restore physiological functions. Using this principle, Swiss doctor Paul? In 1931, Professor Niehausen pioneered fresh live cell therapy and proved it through clinical surgery. Subsequently, the four seasons of Martin Claus? Dr. Martin, the president of the Federal Association of German Fresh Living Cell Therapists and the founder of the Four Seasons Hospital and Health Center in Germany, continued to concentrate on research for more than 40 years and successfully applied this technology to the field of anti-aging.

Four Seasons Martin's fresh living cell therapy uses pure-bred German goats to extract sheep embryo cells from 13 to 17 weeks old to make living cell preparations. After the preparation is injected into the human body, the cell information carried on the fresh living cells performs cell identification with the cells of the corresponding organ through the cell communication network, causing the human cells to produce corresponding response responses. In this way, those aging and damaged cells will be reactivated, thereby restoring the normal physiological functions of organs and the body. There is no specific immune signal on the living cells extracted from goat embryo cells, so it will not cause an immune response of the human immune system after entering the human body, and is a non-rejecting biological agent.

With the continuous deepening of research on fresh living cell therapy, it is now not limited to the treatment of anti-aging fields. Four Seasons Martin has widely applied this technology in the treatment of diabetes, sub-health, cardiovascular disease and other fields, and has achieved Very good effect.

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