Let renewable energy technology truly achieve regeneration

Let renewable energy technology truly achieve regeneration
Bacteria's resistance to antibiotics is one of the biggest challenges in the medical field. Researchers at the Albert Einstein College of Medicine at the University of Yeshua have developed a new generation of antibiotic compounds that will not cause bacterial resistance, which can be safely applied to the human body. The research is published in the latest issue of "Chemical Biology" "Magazine.
These compounds are mainly aimed at two "notorious" bacteria-Vibrio cholerae that causes cholera and E. coli 0157: H7 derived from food contaminants, which causes about 110,000 people to get sick and 50 deaths each year in the United States.
Most antibiotics performed very well at first, almost completely killing the cells they attacked, but through mutation and the pressure of antibiotics to survive the survival of the fittest, many bacterial cells can always escape, multiply, and appear resistant bacteria .
The study was led by Dr. Fern Schellman, who believes that antibiotics that reduce the infectivity of bacteria but do not kill the bacteria can reduce the risk of future drug resistance. Previous research also proved that bacteria communicate with each other by generating and detecting signaling molecules called self-inducers (self-inducers can coordinate the expression of bacterial genes and adjust some processes including the application of toxicity). induction". Strains that are defective in quorum sensing cause less serious infections. Therefore, interfering with group sensing has become the direction of efforts.
In addition to killing Vibrio cholerae and E. coli, the researchers' goal was to disrupt the bacteria's ability to communicate through quorum sensing. The researchers found that the bacterial enzyme MTAN is involved in the synthesis of self-inducers that play a key role in quorum sensing. They have designed enzymes. Compared with the natural enzymes of MTAN, MTAN can be more tightly integrated with the designed effect. This effect always "locks" MTAN and prohibits it from adding boost to crowd sensing.
In this study, Schellman and colleagues tested three compounds that block quorum sensing channels. These three compounds are very effective in disturbing the quorum sensing of Vibrio cholerae and E. coli. In order to know whether the bacteria are Drug resistance will be developed, and the researchers tested the subsequent 25-generation analogs of these two bacteria, and the results showed that the 26th generation was as sensitive to antibiotics as the first.
Schellman called these objects permanent antibiotics. He believes that many other aggressive bacterial pathogens-Streptococcus pneumoniae, Neisseria meningitidis, Klebsiella pneumoniae, and Staphylococcus aureus express MTAN, and therefore may compare these compounds sensitive.
Schellman has developed more than 20 powerful MTAN inhibitors, all of which can be safely used in humans, because MTAN is a bacterial enzyme that prevents it from affecting human metabolism.

Let renewable energy technology truly achieve regeneration

We are the manufacturer of disposable Wooden Tableware integrating production and sales. Mainly operating Disposable Chopsticks, toothpicks,  knives, Forks And Spoons ,spork,ice cream sticks,ice cream spoons,  Coffee Sticks etc productions.The material is made from the birch and poplar. Our products are well popular by customers and are applied in the company, restaurants and families etc place.

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